Structure and expression of human thrombomodulin, ...[EMBO J. 1987]

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1: EMBO J. 1987 Jul;6(7):1891-7. Links

Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation.

Suzuki K, Kusumoto H, Deyashiki Y, Nishioka J, Maruyama I, Zushi M, Kawahara S, Honda G, Yamamoto S, Horiguchi S.

Department of Laboratory Medicine, Mie University School of Medicine, Japan.

We have deduced the entire 575-amino acid sequence of the human thrombomodulin precursor from cDNA clones. The precursor starts with an 18-residue signal peptide domain, followed by the NH2-terminal domain, a domain with six epidermal growth factor-like structures, an O-glycosylation site-rich domain, a 24-residue transmembrane domain and a cytoplasmic domain. Simian COS cells transfected with the expression vector pSV2 containing thrombomodulin cDNA synthesized immunoreactive and functionally active thrombomodulin.

PMID: 2820710 [PubMed - indexed for MEDLINE]

PMCID: PMC553573

Functional domains of membrane-bound human thrombomodulin. EGF-like domains four to six and the serine/threonine-rich domain are required for cofactor activity. [J Biol Chem. 1992]
Microthrombomodulin. Residues 310-486 from the epidermal growth factor precursor homology domain of thrombomodulin will accelerate protein C activation. [J Biol Chem. 1989]
A domain composed of epidermal growth factor-like structures of human thrombomodulin is essential for thrombin binding and for protein C activation. [J Biol Chem. 1989]
Further localization of binding sites for thrombin and protein C in human thrombomodulin. [J Biol Chem. 1990]
Gene structure of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for thrombin-catalyzed activation of protein C. [Nippon Ketsueki Gakkai Zasshi. 1988]
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Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation.

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