A double blind trial comparing clobetasone butyrate cream with hydrocortisone cream was undertaken in 21 children with bilateral eczema. The design of the study was controlled, double blind and randomised. Both the treatment significantly reduced the scores from intitial values and after lst, 2nd and 3rd weeks of treatment. At all periods, the reductions in pre- treatment total scores have been greater for Clobetasone as compared to hydrocortisone, the difference becoming significant at the end of 3 weeks of treatment. 63% patients showed preference to Clobetasone as against 37% who preferred hydrocortisone. No side effects were observed.