Monodisperse selenium-substituted hydroxyapatite: Controllable synthesis and biocompatibility

Jianpeng Sun; Xiaoyan Zheng; Hui Li; Daidi Fan; Zhanping Song; Haixia Ma; Xiufu Hua; Junfeng Hui

doi:10.1016/j.msec.2016.12.106

Monodisperse selenium-substituted hydroxyapatite: Controllable synthesis and biocompatibility

Mater Sci Eng C Mater Biol Appl. 2017 Apr 1:73:596-602. doi: 10.1016/j.msec.2016.12.106. Epub 2016 Dec 24.

Authors

Jianpeng Sun¹, Xiaoyan Zheng², Hui Li², Daidi Fan², Zhanping Song³, Haixia Ma², Xiufu Hua⁴, Junfeng Hui⁵

Affiliations

¹ School of Civil Engineering, Xi'an University of Architecture and Technology, Shaanxi 710055, PR China; Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical and Engineering, Northwest University, Xi'an, 710069, PR China.
² Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical and Engineering, Northwest University, Xi'an, 710069, PR China.
³ School of Civil Engineering, Xi'an University of Architecture and Technology, Shaanxi 710055, PR China.
⁴ Department of Scientific Research and Development, Tsinghua University, Beijing 100084, PR China. Electronic address: hua_xiufu@163.com.
⁵ Shaanxi Key Laboratory of Degradable Biomedical Materials, Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical and Engineering, Northwest University, Xi'an, 710069, PR China. Electronic address: huijunfeng@126.com.

PMID: 28183650
DOI: 10.1016/j.msec.2016.12.106

Abstract

Hydroxyapatite (HA) is the major inorganic component of natural bone tissue. As an essential trace element, selenium involves in antioxidation and anticancer of human body. So far, ion-doped hydroxyapatites (HAs) are widely investigated owing to their great applications in field of biomaterial, biological labeling. In this paper, series of monodisperse HA doped with SeO₃^2- (SeHA) was successfully synthesized based on the liquid-solid-solution (LSS) strategy. The obtained samples were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and energy-dispersive spectrometer (EDS). The results indicated that the SeO₃^2- doping level of the Se/(P+Se) molar ratio of 0-0.4 can be requisitely controlled, and the morphology of SeHA nanoparticles varied from nanorods to nanoneedles with increasing Se/(P+Se) molar ratio. Significantly, the as-synthesized SeHA nanocrystals exhibit a low cytotoxicity for osteoblastic cells, showing exciting potentials for application in artificial scaffold materials inhibiting of tumor growth in bone.

Keywords: Biocompatibility; Controllable synthesis; Hydroxyapatite; Selenium.

MeSH terms

Animals
Biocompatible Materials / chemical synthesis*
Biocompatible Materials / pharmacology*
Cell Death / drug effects
Cell Line
Cell Shape / drug effects
Durapatite / chemical synthesis*
Durapatite / chemistry
Durapatite / pharmacology*
Materials Testing*
Mice
Nanoparticles / chemistry
Nanoparticles / ultrastructure
Selenium / chemistry*
Selenium / pharmacology
Spectroscopy, Fourier Transform Infrared
X-Ray Diffraction

Substances

Biocompatible Materials
Durapatite
Selenium