Whole-exome sequencing analysis of supernumerary teeth occurrence in Japanese individuals

Masahiro Takahashi; Kazuyoshi Hosomichi; Tetsutaro Yamaguchi; Keisuke Yano; Takahiro Funatsu; Mohamed Adel; Shugo Haga; Koutaro Maki; Atsushi Tajima

doi:10.1038/hgv.2016.46

Whole-exome sequencing analysis of supernumerary teeth occurrence in Japanese individuals

Hum Genome Var. 2017 Jan 26:4:16046. doi: 10.1038/hgv.2016.46. eCollection 2017.

Authors

Masahiro Takahashi¹, Kazuyoshi Hosomichi², Tetsutaro Yamaguchi¹, Keisuke Yano³, Takahiro Funatsu⁴, Mohamed Adel¹, Shugo Haga¹, Koutaro Maki¹, Atsushi Tajima²

Affiliations

¹ Department of Orthodontics, School of Dentistry, Showa University , Tokyo, Japan.
² Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University , Ishikawa, Japan.
³ Verde Orthodontic Dental Clinic , Tokyo, Japan.
⁴ Division of Dentistry for Persons with Disabilities, Department of Special Needs Dentistry, School of Dentistry, Showa University , Tokyo, Japan.

Abstract

A common disorder of human dentition is the existence of supernumerary teeth. Impacted supernumerary teeth occur most frequently in the maxillary incisor area and are termed mesiodens. We conducted whole-exome sequencing of non-syndromic Japanese individuals possessing supernumerary teeth to identify genes and/or loci involved in the pathogenesis of the condition.