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Psychopharmacology (Berl). 1989;99 Suppl:S64-7.

Predictors of response to clozapine therapy.

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  • 1Sandoz Research Institute, East Hanover, NJ 07936.

Abstract

Multiple regression analysis and discriminant function analyses were applied to the question of prediction of therapeutic success or failure to clozapine therapy, using a non-biological predictor pool of 46 items. This effort was not successful, accounting for less than 25% of outcome variance under optimal conditions. However, it does appear that while clozapine efficacy in treatment-resistant schizophrenic patients in general is superior to such neuroleptics as chlorpromazine or haloperidol, the "paranoid" subgroup appears to benefit most.

PMID:
2813666
[PubMed - indexed for MEDLINE]
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