[Inhibition of the adhesiveness and proliferation of gingival fibroblasts induced by short-chain fatty acids produced by anaerobic bacteria]

C Eftimiadi; M Tonetti; A Zicca; A Cadoni; R Mangione; A Gandolfo; P E Mangiante

[Inhibition of the adhesiveness and proliferation of gingival fibroblasts induced by short-chain fatty acids produced by anaerobic bacteria]

Minerva Stomatol. 1989 Aug;38(8):819-22.

[Article in Italian]

Authors

C Eftimiadi, M Tonetti, A Zicca, A Cadoni, R Mangione, A Gandolfo, P E Mangiante

PMID: 2811791

Abstract

Short-chain fatty acids produced by anaerobic bacteria inhibit attachment and proliferation of gingival fibroblasts. Butyric acid, at concentration normally present in periodontal pockets, produced the highest degree of activity.

Publication types

English Abstract

MeSH terms

Bacteria, Anaerobic / metabolism*
Butyrates / metabolism
Butyrates / pharmacology
Cell Adhesion / drug effects
Cell Division / drug effects
Dose-Response Relationship, Drug
Fatty Acids, Volatile / biosynthesis
Fatty Acids, Volatile / pharmacology*
Fibroblasts / cytology
Fibroblasts / drug effects*
Gingiva / cytology*
Gingiva / drug effects
Growth Inhibitors / biosynthesis
Humans
Propionates / metabolism
Propionates / pharmacology
Succinates / metabolism
Succinates / pharmacology
Succinic Acid

Substances

Butyrates
Fatty Acids, Volatile
Growth Inhibitors
Propionates
Succinates
Succinic Acid