J Nucl Med. 1989 Nov;30(11):1838-42.

A new zinc-62/copper-62 generator as a copper-62 source for PET radiopharmaceuticals.

Fujibayashi Y, Matsumoto K, Yonekura Y, Konishi J, Yokoyama A.

Source

Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.

Abstract

A new 62Zn/62Cu generator system was designed to provide a readily available 62Cu source for positron emission tomographic radiopharmaceuticals, based on the differences of complex formation between Zn and Cu. Noncarrier added 62Cu was selectively eluted as a glycine complex from 62Zn-adsorbed cation-exchange resin (CG-120, Amberlite), when a glycine solution (200 mM) was used as the eluant. The elution efficiency and radionuclidic purity of 62Cu were 70% and greater than 99.9%, respectively. Copper in glycine solution showed rapid complex formation with dithiosemicarbazone, which is one of the established Cu-binding agents for bifunctional chelating radiopharmaceutical.

PMID:: 2809748; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Supplemental Content

Related citations

Development of a high performance zinc-62/copper-62 radionuclide generator for positron emission tomography. [Eur J Nucl Med. 1992]
Development of a high performance zinc-62/copper-62 radionuclide generator for positron emission tomography.
Zweit J, Goodall R, Cox M, Babich JW, Potter GA, Sharma HL, Ott RJ. Eur J Nucl Med. 1992; 19(6):418-25.
Performance of a 62Zn/62Cu generator in clinical trials of PET perfusion agent 62Cu-PTSM. [J Nucl Med. 2000]
Performance of a 62Zn/62Cu generator in clinical trials of PET perfusion agent 62Cu-PTSM.
Haynes NG, Lacy JL, Nayak N, Martin CS, Dai D, Mathias CJ, Green MA. J Nucl Med. 2000 Feb; 41(2):309-14.
An improved 62Zn/62Cu generator based on a cation exchanger and its fully remote-controlled preparation for clinical use. [Nucl Med Biol. 2006]
An improved 62Zn/62Cu generator based on a cation exchanger and its fully remote-controlled preparation for clinical use.
Fukumura T, Okada K, Suzuki H, Nakao R, Mukai K, Szelecsényi F, Kovács Z, Suzuki K. Nucl Med Biol. 2006 Aug; 33(6):821-7. Epub 2006 Jul 21.
Review An overview of copper radionuclides and production of 61Cu by proton irradiation of (nat)Zn at a medical cyclotron. [Appl Radiat Isot. 2006]
Review An overview of copper radionuclides and production of 61Cu by proton irradiation of (nat)Zn at a medical cyclotron.
Rowshanfarzad P, Sabet M, Jalilian AR, Kamalidehghan M. Appl Radiat Isot. 2006 Dec; 64(12):1563-73. Epub 2005 Dec 27.
Review Overview of the current status of PET in breast cancer imaging. [Q J Nucl Med. 1998]
Review Overview of the current status of PET in breast cancer imaging.
Wahl RL. Q J Nucl Med. 1998 Mar; 42(1):1-7.

See reviews... See all...

Cited by 1 PubMed Central article

Review Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease. [Chem Rev. 2010]
Review Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease.
Wadas TJ, Wong EH, Weisman GR, Anderson CJ. Chem Rev. 2010 May 12; 110(5):2858-902.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

A new zinc-62/copper-62 generator as a copper-62 source for PET radiopharmaceuti...
A new zinc-62/copper-62 generator as a copper-62 source for PET radiopharmaceuticals.
J Nucl Med. 1989 Nov ;30(11):1838-42.

PubMed
Effect of food composition on vitamin K absorption in human volunteers.
Effect of food composition on vitamin K absorption in human volunteers.
Br J Nutr. 1996 Aug ;76(2):223-9.

PubMed
A family approach to cardiovascular risk reduction: results from the San Diego F...
A family approach to cardiovascular risk reduction: results from the San Diego Family Health Project.
Health Educ Q. 1989 Summer ;16(2):229-44.

PubMed
Studies on the bristle pattern of Drosophila.
Studies on the bristle pattern of Drosophila.
Dev Biol. 1970 Feb ;21(1):48-61.

PubMed
CT diagnosis of tumor thrombus in the inferior vena cava: avoiding the false-pos...
CT diagnosis of tumor thrombus in the inferior vena cava: avoiding the false-positive diagnosis.
AJR Am J Roentgenol. 1981 Dec ;137(6):1265-7.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

A new zinc-62/copper-62 generator as a copper-62 source for PET radiopharmaceuticals.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 1 PubMed Central article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information