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J Am Acad Dermatol. 1989 Oct;21(4 Pt 1):714-6.

Comparative efficacy of 12% ammonium lactate lotion and 5% lactic acid lotion in the treatment of moderate to severe xerosis.

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  • 1Department of Dermatology, Mayo Clinic, Rochester, Minnesota.


This double-blind study was designed to evaluate treatment results and time effects of 12% ammonium lactate and 5% lactic acid lotion for moderate to severe xerosis. Results showed 12% ammonium lactate lotion was significantly more effective than 5% lactic acid lotion in reducing the severity of xerosis in both the 3-week, twice-a-day treatment period and the following 3-week, no-treatment (regression) period.

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