Abstract
We report a case of a child with pre-B cell acute lymphoblastic leukemia undergoing maintenance chemotherapy with 6-mercaptopurine and methotrexate (MTX) who developed sinusoidal obstruction syndrome after being treated with ciprofloxacin for BK viremia. This case represents a rare complication of maintenance therapy with MTX and 6-mercaptopurine, and suggests a drug interaction between ciprofloxacin and MTX.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Biomarkers
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Biopsy
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Child
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Drug Interactions
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Hepatic Veno-Occlusive Disease / diagnosis*
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Hepatic Veno-Occlusive Disease / etiology*
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Hepatic Veno-Occlusive Disease / therapy
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Humans
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Maintenance Chemotherapy / adverse effects
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Male
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Mercaptopurine / administration & dosage
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Methotrexate / administration & dosage
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Multimodal Imaging / methods
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
Substances
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Biomarkers
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Mercaptopurine
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Methotrexate