Sinusoidal Obstruction Syndrome During Maintenance Therapy for Acute Lymphoblastic Leukemia With 6-Mercaptopurine and Methotrexate: A Pediatric Case Report

J Pediatr Hematol Oncol. 2017 Nov;39(8):e454-e455. doi: 10.1097/MPH.0000000000000776.

Abstract

We report a case of a child with pre-B cell acute lymphoblastic leukemia undergoing maintenance chemotherapy with 6-mercaptopurine and methotrexate (MTX) who developed sinusoidal obstruction syndrome after being treated with ciprofloxacin for BK viremia. This case represents a rare complication of maintenance therapy with MTX and 6-mercaptopurine, and suggests a drug interaction between ciprofloxacin and MTX.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / adverse effects*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biomarkers
  • Biopsy
  • Child
  • Drug Interactions
  • Hepatic Veno-Occlusive Disease / diagnosis*
  • Hepatic Veno-Occlusive Disease / etiology*
  • Hepatic Veno-Occlusive Disease / therapy
  • Humans
  • Maintenance Chemotherapy / adverse effects
  • Male
  • Mercaptopurine / administration & dosage
  • Methotrexate / administration & dosage
  • Multimodal Imaging / methods
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy

Substances

  • Biomarkers
  • Mercaptopurine
  • Methotrexate