Low Pretreatment Lymphocyte-Monocyte Ratio and High Platelet-Lymphocyte Ratio Indicate Poor Cancer Outcome in Early Tongue Cancer

Hui Shan Ong; Sandhya Gokavarapu; Li Zhen Wang; Zhen Tian; Chen Ping Zhang

doi:10.1016/j.joms.2016.12.023

Low Pretreatment Lymphocyte-Monocyte Ratio and High Platelet-Lymphocyte Ratio Indicate Poor Cancer Outcome in Early Tongue Cancer

J Oral Maxillofac Surg. 2017 Aug;75(8):1762-1774. doi: 10.1016/j.joms.2016.12.023. Epub 2016 Dec 26.

Authors

Hui Shan Ong¹, Sandhya Gokavarapu², Li Zhen Wang³, Zhen Tian³, Chen Ping Zhang⁴

Affiliations

¹ Resident, Department of Oral and Maxillofacial-Head & Neck Oncology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Consultant in Head and Neck Oncology Reconstructive Surgery, Department of Surgical Oncology, Krishna Institute of Medical Science, Hyderabad, India.
³ Professor and Consultant, Department of Oral Pathology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁴ Head of Department and Professor, Department of Oral and Maxillofacial-Head & Neck Oncology, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: zhagchenping@gmail.com.

PMID: 28063763
DOI: 10.1016/j.joms.2016.12.023

Abstract

Purpose: The white blood cell (WBC) indices have been reported to have a prognostic impact in cancer of multiple organs including head and neck cancer; however; site and stage stratification was not attempted, and compelling evidence has shown that early cancers have a different distribution and prognostic ability than late-stage cancers. We studied the prognostic importance of WBC indices in early oral tongue cancers.

Patients and methods: The retrospective data of primary pT1N0 to pT2N0 oral tongue cancers treated between 2009 and 2013 were charted. WBC indices such as the neutrophil count, lymphocyte count (LC), platelet count (PC), and monocyte count, along with derived indices such as the neutrophil-lymphocyte ratio, platelet-lymphocyte ratio (PLR), and lymphocyte-monocyte ratio (LMR), were analyzed by multivariate analysis with other clinicopathologic prognostic factors.

Results: A total of 133 patients fulfilled the inclusion criteria; the minimum follow-up period for living patients was 36 months. A total of 22 patients reported disease relapse, and 11 patients died of disease. Multivariate analysis showed LC (hazard ratio [HR], 0.206; 95% confidence interval [CI], 0.092 to 0.46; P < .001), PC (HR, 1.011; 95% CI, 1.001 to 1.021; P = .026), PLR (HR, 1.012; 95% CI, 1.008 to 1.016; P < .001), and LMR (HR, 0.721; 95% CI, 0.596 to 0.872; P = .001) are significant independent prognostic factors for disease-free survival. Distant metastasis (HR, 9.014; 95% CI, 2.303 to 38.914; P = .004), LC (HR, 0.091; 95% CI, 0.015 to 0.558; P = .01), PC (HR, 1.023; 95% CI, 1.006 to 1.041; P = .009), PLR (HR, 1.016; 95% CI, 1.004 to 1.027; P = .002), and LMR (HR, 0.58; 95% CI, 0.387 to 0.868; P = .008) are significant independent prognostic factors for overall survival.

Conclusions: Low pretreatment LMR and high PLR indicate poor survival in patients with early tongue cancer. We suggest close follow-up for this subgroup despite radical resection with clear margins.

MeSH terms

Adult
Aged
Disease-Free Survival
Female
Follow-Up Studies
Humans
Leukocyte Count*
Lymphocyte Count*
Male
Middle Aged
Monocytes*
Multivariate Analysis
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Recurrence, Local / blood
Neoplasm Recurrence, Local / mortality
Neoplasm Recurrence, Local / pathology
Neoplasm Recurrence, Local / surgery
Neoplasm Staging
Platelet Count*
Prognosis
Retrospective Studies
Survival Rate
Tongue Neoplasms / blood*
Tongue Neoplasms / mortality
Tongue Neoplasms / pathology
Tongue Neoplasms / surgery*
Treatment Outcome*