Agents Actions. 1989 Jun;27(3-4):332-4.

Kaolin-induced writhing in mice, a new model of possible bradykinin-induced pain for assessment of analgesic agents.

Fujiyoshi T, Hayashi I, Ohishi S, Kuwashima M, Iida H, Dozen M, Taniguchi N, Ikeda K, Ohnishi H.

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Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.

Abstract

Kaolin induced a clear and reproducible writhing reaction when intraperitoneally injected into mice. A simultaneous injection (i.p.) of soybean trypsin inhibitor (SBTI) significantly suppressed the kaolin-induced writhing reaction. This writhing reaction was markedly potentiated by a simultaneous injection (i.p.) of captopril. In an in vitro experiment kaolin caused kinin-release in mouse plasma, possibly through the activation of prekallikrein. This activation of plasma prekallikrein and kinin-release were inhibited in the presence of SBTI. Some non-steroidal anti-inflammatory agents inhibited the kaolin-induced writhing reaction dose-dependently. These results suggest that kaolin-induced writhing reaction may be caused by the released bradykinin through activation of the plasma kallikrein-kinin system. This model is a novel and simple tool for assessment of analgesic agents.

PMID:: 2801319; [PubMed - indexed for MEDLINE]

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