[Studies on synthesis of baogongteng A--a new myotic agent]

Yao Xue Xue Bao. 1989;24(2):105-9.
[Article in Chinese]

Abstract

Baogongteng A, isolated from Erycibe obtusifolia Benth., is a new tropane alkaloid used for treating glaucoma. Using synthetic 6 beta-acetoxy-tropinone as starting material, racemic Baogongteng A(8) was synthesized. Synthetic Baogongteng A also shows myotic activities in rabbits, but the potency is half of that of the natural product.

MeSH terms

  • Bridged Bicyclo Compounds / chemical synthesis*
  • Bridged Bicyclo Compounds, Heterocyclic*
  • Bridged-Ring Compounds / chemical synthesis*
  • Miotics / chemical synthesis*
  • Tropanes

Substances

  • Bridged Bicyclo Compounds
  • Bridged Bicyclo Compounds, Heterocyclic
  • Bridged-Ring Compounds
  • Miotics
  • Tropanes
  • bao gong teng A