A Genome-Wide Association Study of Basal Transepidermal Water Loss Finds that Variants at 9q34.3 Are Associated with Skin Barrier Function

Manfei Zhang; Bingjie Li; Sijie Wu; Jingze Tan; Yajun Yang; Alessandra Marini; Andrea Vierkötter; Juan Zhang; Hui Li; Tamara Schikowski; Li Jin; Jean Krutmann; Sijia Wang

doi:10.1016/j.jid.2016.11.030

A Genome-Wide Association Study of Basal Transepidermal Water Loss Finds that Variants at 9q34.3 Are Associated with Skin Barrier Function

J Invest Dermatol. 2017 Apr;137(4):979-982. doi: 10.1016/j.jid.2016.11.030. Epub 2016 Dec 21.

Authors

Manfei Zhang¹, Bingjie Li², Sijie Wu², Jingze Tan³, Yajun Yang⁴, Alessandra Marini⁵, Andrea Vierkötter⁵, Juan Zhang⁴, Hui Li³, Tamara Schikowski⁵, Li Jin⁶, Jean Krutmann⁵, Sijia Wang⁷

Affiliations

¹ State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China; Chinese Academy of Sciences Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
² Chinese Academy of Sciences Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, China.
³ State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China.
⁴ State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China; Fudan-Taizhou Institute of Health Sciences, 1 Yaocheng Road, Taizhou, Jiangsu 225300, China.
⁵ IUF-Leibniz Research Institute for Environmental Medicine, Duesseldorf, Germany.
⁶ State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China; Chinese Academy of Sciences Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Fudan-Taizhou Institute of Health Sciences, 1 Yaocheng Road, Taizhou, Jiangsu 225300, China.
⁷ State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai 200438, China; Chinese Academy of Sciences Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. Electronic address: wangsijia@picb.ac.cn.

PMID: 28011148
DOI: 10.1016/j.jid.2016.11.030

No abstract available

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Body Water / metabolism*
Chromosomes, Human, Pair 9*
Genome-Wide Association Study*
Humans
Middle Aged
Polymorphism, Single Nucleotide
Skin / metabolism*
Water Loss, Insensible / physiology*