Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus

S V Michurina; I Yu Ishchenko; S A Arkhipov; V V Klimontov; L N Rachkovskaya; V I Konenkov; E L Zavyalov

doi:10.1007/s10517-016-3592-y

Effects of Melatonin, Aluminum Oxide, and Polymethylsiloxane Complex on the Expression of LYVE-1 in the Liver of Mice with Obesity and Type 2 Diabetes Mellitus

Bull Exp Biol Med. 2016 Dec;162(2):269-272. doi: 10.1007/s10517-016-3592-y. Epub 2016 Dec 1.

Authors

S V Michurina^{1

2}, I Yu Ishchenko^{3

4}, S A Arkhipov^{3

4}, V V Klimontov^{3

4}, L N Rachkovskaya^{3

4}, V I Konenkov^{3

4}, E L Zavyalov^{3

4}

Affiliations

¹ Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia. s.michurina@ngs.ru.
² Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia. s.michurina@ngs.ru.
³ Research Institute of Clinical and Experimental Lymphology, Novosibirsk, Russia.
⁴ Federal Research Center, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.

PMID: 27909960
DOI: 10.1007/s10517-016-3592-y

Abstract

The effects of melatonin, aluminum oxide, and polymethylsiloxane complex on the expression of LYVE-1 (lymphatic vessel endothelial hyaluronan receptor) in the liver were studied in db/db mice with experimental obesity and type 2 diabetes mellitus. The complex or placebo was administered daily by gavage from week 8 to week 16 of life. The animals receiving the complex exhibited enhanced, in comparison with the placebo group, immunohistochemical LYVE-1+ staining of endothelial cells in sinusoids. Enhanced expression of LYVE-1 was associated with less pronounced dilatation of interlobular arteries, veins, and lymphatic vessels. Thee findings suggest a protective effect of the complex towards structural changes in the liver of mice with obesity and type 2 diabetes.

Keywords: LYVE-1; liver; melatonin; sinusoidal cells; type 2 diabetes mellitus.

MeSH terms

Aluminum Oxide / chemistry
Animals
Antioxidants / pharmacology*
Blood Glucose / metabolism
Diabetes Mellitus, Type 2 / drug therapy*
Diabetes Mellitus, Type 2 / genetics
Diabetes Mellitus, Type 2 / metabolism
Diabetes Mellitus, Type 2 / pathology
Disease Models, Animal
Endothelial Cells / drug effects
Endothelial Cells / metabolism
Endothelial Cells / pathology
Female
Gene Expression / drug effects
Glycoproteins / agonists*
Glycoproteins / genetics
Glycoproteins / metabolism
Hepatic Artery / drug effects
Hepatic Artery / metabolism
Hepatic Artery / pathology
Homozygote
Hyperglycemia / drug therapy*
Hyperglycemia / genetics
Hyperglycemia / metabolism
Hyperglycemia / pathology
Liver / drug effects
Liver / metabolism
Liver / pathology
Lymphatic Vessels / drug effects
Lymphatic Vessels / metabolism
Lymphatic Vessels / pathology
Melatonin / pharmacology*
Membrane Transport Proteins
Mice
Mice, Transgenic
Obesity / drug therapy*
Obesity / genetics
Obesity / metabolism
Obesity / pathology
Receptors, Leptin / deficiency
Receptors, Leptin / genetics
Silicones / chemistry

Substances

Antioxidants
Blood Glucose
Glycoproteins
Membrane Transport Proteins
Receptors, Leptin
Silicones
Xlkd1 protein, mouse
leptin receptor, mouse
polymethylsiloxane
Melatonin
Aluminum Oxide