Objective: To investigate the potential dose-response relationship between PCDD/Fs inhalational exposure and oxidative damage to DNA and lipid in foundry workers. Methods: The participants were divided into three groups, including exposure group, administrator group and control group. The concentrations of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in air environment were determined by isotope dilution high resolution capillary column gas chromatography/high resolution mass spectrometry (HRGC-HRMS). The inhalational dose of PCDD/Fs were evaluated by Houmen's model. Urinary 8-OHdG was analyzed by high performance liquid chromatography-electrochemical detector (HPLC-ECD). Urinary 8-iso-PGF2ɑ were determined by ELISA. Results: The PCDD/Fs environmental concentrations of three groups (pg·TEQ/m) were 0.21±0.08, 0.03±0.01, 0.0012±0.0007 (P<0.05) , respectively. The inhalational dose of exposure group (92.54 (32.90~264.49) fg·TEQ/kg·d) was 5.4 folds higher than the administrator group, and was 201 times more than control group. The levels of urinary 8-OHdG (nmol/L crea) of three groups were 3.25 (1.07~15.36) , 2.72 (0.75~16.07) , 2.17 (0.38~17.07) (P<0.05) and the levels of urinary 8-iso-PGF2ɑ (nmol/L crea) were 19.11 (9.33~76.50) , 20.95 (8.40~79.31) , 11.48 (4.85~37.80) (P<0.05) , respectively. The multiple linear regression analysis revealed that there were significantly increased trend for levels of urinary 8-OHdG and 8-iso-PGF2ɑ as PCDD/Fs exposure levels increased, after adjustment for age, sex, smoking statue, alcohol use and BMI (P<0.01). Conclusion: There was a dose-response relationship between PCDD/Fs inhalational exposure and oxidative damage in foundry workers.