Science. 1978 Aug 18;201(4356):628-30.

Lymphocyte ecto-5'-nucleotidase deficiency in agammaglobulinemia.

Edwards NL, Magilavy DB, Cassidy JT, Fox IH.

Abstract

Fresh peripheral blood lymphocytes from eight patients with congenital agammaglobulinemia demonstrate reduced ecto-5'-nucleotidase activity when compared to the mean activity of normal subjects and patients with other forms of immunoglobulin deficiency. A specific defect of ecto-5'-nucleotidase is further suggested by normal values for lymphocyte ecto-adenosinetriphosphatase and ecto-nonspecific phosphatase. The data provide evidence for an enzyme deficiency in this X-linked, B lymphocyte deficiency syndrome.

PMID:: 27864; [PubMed - indexed for MEDLINE]

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Research Support, U.S. Gov't, P.H.S.

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Nucleotidases

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Ecto-5'-nucleotidase activity in T and B lymphocytes from normal subjects and patients with congenital X-linked agammaglobulinemia. [J Immunol. 1979]
Ecto-5'-nucleotidase activity in T and B lymphocytes from normal subjects and patients with congenital X-linked agammaglobulinemia.
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