A Powerful CD8+ T-Cell Stimulating D-Tetra-Peptide Hydrogel as a Very Promising Vaccine Adjuvant

Adv Mater. 2017 Feb;29(5). doi: 10.1002/adma.201601776. Epub 2016 Nov 14.

Abstract

A novel vaccine adjuvant based on a supramolecular hydrogel of a D-tetra-peptide is reported. Antigens can be easily incorporated into the hydrogel by a vortex or by gently shaking before injection. The vaccines can stimulate strong CD8+ T-cell responses, which significantly inhibits tumor growth. This novel adjuvant is expected to enable a wide range of sub-unit vaccines and help the production of antibodies.

Keywords: adjuvants; cancer therapy; hydrogels; peptides; vaccines.

MeSH terms

  • Adjuvants, Immunologic
  • CD8-Positive T-Lymphocytes*
  • Hydrogels
  • Peptides
  • Vaccines

Substances

  • Adjuvants, Immunologic
  • Hydrogels
  • Peptides
  • Vaccines