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Brain Res. 1989 Apr 10;484(1-2):352-6.

Influence of epidermal growth factor on long-term potentiation in the hippocampal slice.

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  • 1Max-Planck-Institut für Biophysikalische Chemie, Department of Neurobiology, Göttingen, F.R.G.


Rat hippocampal slices were perfused with epidermal growth factor (EGF) at a concentration of 10(-8) M. EGF is a well known mitogen which exhibits neurotrophic action on neurons of the CNS. During extra- and intracellular recordings in the pyramidal cell body layer of the CA1-region no influence of EGF on evoked potentials was seen if single-pulse or paired-pulse stimulation was used. Furthermore EGF has no influence on the resting membrane potential of the cells investigated. However after tetanic stimulation a significant increase in the magnitude of long-term potentiation was observed. Therefore it is concluded, that EGF might be involved in modulation of neuronal plasticity.

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