Rescuing the guardian of the genome

Science. 2016 Oct 7;354(6308):26-28. doi: 10.1126/science.354.6308.26.
No abstract available

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / therapeutic use
  • Computer Simulation
  • DNA / chemistry
  • DNA / metabolism
  • Drug Design
  • Drugs, Investigational
  • Genome, Human
  • Humans
  • Mice
  • Mutation
  • Neoplasms / drug therapy*
  • Neoplasms / genetics*
  • Protein Binding
  • Protein Conformation
  • Rats
  • Small Molecule Libraries / chemistry*
  • Tumor Suppressor Protein p53 / chemistry
  • Tumor Suppressor Protein p53 / genetics*
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • Antineoplastic Agents
  • Drugs, Investigational
  • Small Molecule Libraries
  • Tumor Suppressor Protein p53
  • DNA