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Proc Natl Acad Sci U S A. 1989 Apr;86(7):2361-4.

Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes.

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  • 1Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.

Abstract

A number of studies have suggested that resistance of target cells to natural killing (NK) may be correlated with their level of expression of major histocompatibility complex (MHC) class I antigens. To examine this hypothesis directly, a NK-sensitive class I-deficient human B-cell line was transfected with MHC class I genes. The expression of transfected HLA, but not H-2, class I gene products resulted in loss of susceptibility to human NK-mediated conjugation and cytolysis. Furthermore, this protection did not extend to cytotoxicity mediated by interleukin 2-stimulated human NK effector cells.

PMID:
2784569
PMCID:
PMC286912
[PubMed - indexed for MEDLINE]
Free PMC Article
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