Send to

Choose Destination
See comment in PubMed Commons below
Proc Natl Acad Sci U S A. 1989 Apr;86(7):2361-4.

Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes.

Author information

  • 1Department of Microbiology and Immunology, Duke University Medical Center, Durham, NC 27710.


A number of studies have suggested that resistance of target cells to natural killing (NK) may be correlated with their level of expression of major histocompatibility complex (MHC) class I antigens. To examine this hypothesis directly, a NK-sensitive class I-deficient human B-cell line was transfected with MHC class I genes. The expression of transfected HLA, but not H-2, class I gene products resulted in loss of susceptibility to human NK-mediated conjugation and cytolysis. Furthermore, this protection did not extend to cytotoxicity mediated by interleukin 2-stimulated human NK effector cells.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk