Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
J Cereb Blood Flow Metab. 1989 Feb;9(1):96-103.

A highly accurate method of localizing regions of neuronal activation in the human brain with positron emission tomography.

Author information

  • 1Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, St. Louis, MO 63110.

Abstract

Functional mapping of the human brain with positron emission tomography (PET) can best be performed by obtaining multiple short measurements of cerebral blood flow in a single sitting. In this manner regional changes in blood flow accompanying the increased neuronal activity from a movement, sensation, or even cognition task, have been identified. However, localizing a functional region with PET has been severely limited by the poor resolving properties of PET devices. Using a new method of data analysis we recently reported the mapping of visual field stimuli on human visual cortex with surprisingly high reliability as measured by the low standard deviation in positions across different subjects (as low as 1 mm). In this work the analysis technique enabling such high-resolution functional brain mapping is fully described. Additionally, simulations are presented to illustrate its advantages and limitations.

PMID:
2783425
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Write to the Help Desk