Association between obstructive sleep apnea and metabolic syndrome: a meta-analysis

Clin Invest Med. 2016 Oct 14;39(5):E161-E172. doi: 10.25011/cim.v39i5.27148.

Abstract

Purpose: Evidence suggests that obstructive sleep apnea (OSA) is related to metabolic syndrome; however, the relationship among metabolic syndrome parameters (blood pressure, fasting blood glucose (FBG), high density lipoprotein (HDL) and low density lipoprotein (LDL)) and OSA is unclear.

Methods: PRISMA guidelines were followed for this study. Medline, Cochrane, EMBASE and Google Scholar databases were searched until December 23, 2015, using following terms: obstructive sleep apnea, sleep apnea, OSA and metabolic syndrome.

Results: Ten studies were included in the analysis which included 2053 patients. Patients with OSA had higher systolic blood pressure (SBP) (pooled standard mean difference (SMD) = 0.56, 95% CI, 0.40 to 0.71, P.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blood Glucose / analysis
  • Cardiovascular Diseases / complications
  • Diabetes Mellitus, Type 2 / complications
  • Female
  • Humans
  • Lipoproteins, HDL / blood
  • Lipoproteins, LDL / blood
  • Male
  • Metabolic Syndrome / complications*
  • Middle Aged
  • Regression Analysis
  • Risk Factors
  • Sleep Apnea, Obstructive / complications*
  • Systole
  • Treatment Outcome
  • Young Adult

Substances

  • Blood Glucose
  • Lipoproteins, HDL
  • Lipoproteins, LDL