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Definitive evidence for hypoxic cells influencing cure in cancer therapy.
From an analysis of 2803 patients with carcinoma of the cervix treated by radiation therapy, a 62% cure rate can be shown. In those patients with Stage IIb and III disease, a haemoglobin level during treatment of below 12 g% was associated with a significantly higher pelvic recurrence rate, and also lower cure rate, than for those with a haemoglobin level 12g% or more. A prospective study shows that the correction of anaemia is associated with a decreased pelvic recurrence rate and an increased cure rate consistent with tumour hypoxia being greater in anaemic patients than in those with a normal haemoglobin level. It is also consistent with the thesis that hypoxia controls the radiation local control rate in patients with advanced carcinoma of the cervix.
PMID: 277250 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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Impact of extracellular acidity on the activity of P-glycoprotein and the cytotoxicity of chemotherapeutic drugs.
Thews O, Gassner B, Kelleher DK, Schwerdt G, Gekle M.
Neoplasia. 2006 Feb; 8(2):143-52.
[Neoplasia. 2006]
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Utilizing tumor hypoxia to enhance oncolytic viral therapy in colorectal metastases.
Reinblatt M, Pin RH, Federoff HJ, Fong Y.
Ann Surg. 2004 Jun; 239(6):892-9; discussion 899-902.
[Ann Surg. 2004]
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Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia.
Yao KS, Xanthoudakis S, Curran T, O'Dwyer PJ.
Mol Cell Biol. 1994 Sep; 14(9):5997-6003.
[Mol Cell Biol. 1994]