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Proc Natl Acad Sci U S A. 1989 Sep;86(17):6793-7.

5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.

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  • 1Howard Hughes Medical Institute, College of Physicians and Surgeons, Columbia University, New York, NY 10032.


Neurons in rat central nervous system (CNS) that express 5-HT1c receptor mRNA have been localized by in situ hybridization histochemistry. The 5-HT1c receptor is expressed in a wide variety of cortical and subcortical neurons including hippocampal pyramidal neurons, neurons within most of the central monoaminergic cell groups, neurons in thalamic sensory relay nuclei, and neurons involved in the central processing and regulation of nociceptive transmission. Therefore, the 5-HT1c receptor is a prominent but poorly characterized central subclass of serotonin (5-HT) receptor. The distribution of the 5-HT1c receptor within the CNS is considerably more widespread than that of the structurally and functionally related 5-HT2 receptor.

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