Copolymer-Mediated Cell Aggregation Promotes a Proangiogenic Stem Cell Phenotype In Vitro and In Vivo

Adv Healthc Mater. 2016 Nov;5(22):2866-2871. doi: 10.1002/adhm.201600819. Epub 2016 Sep 26.

Abstract

Material-induced cell aggregation drives a proangiogenic expression profile. Copolymer substrates containing cell-repellent and cell-adhesive domains force the aggregation of human mesenchymal stem cells, which results in enhanced tubulogenesis in vitro and stabilization of vasculature in vivo. These findings can be used to design instructive biomaterial scaffolds for clinical use.

Keywords: angiogenesis; cell-material interface; inflammation; mesenchymal stem cells; outside-in signaling; synthetic copolymers.

MeSH terms

  • Biocompatible Materials / administration & dosage*
  • Cell Aggregation / drug effects*
  • Cells, Cultured
  • Humans
  • Mesenchymal Stem Cells / drug effects*
  • Phenotype
  • Polymers / administration & dosage*
  • Tissue Scaffolds / chemistry

Substances

  • Biocompatible Materials
  • Polymers