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Ophthalmology. 1989 Jul;96(7):1048-52; discussion 1052-3.

Methylprednisolone pulse therapy in severe dysthyroid optic neuropathy.

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  • 1Department of Ophthalmology, University of Florida, College of Medicine, Gainesville 32610-0284.


Five patients with severe dysthyroid optic neuropathy were treated with intravenous methylprednisolone (1 g daily for 3 consecutive days). Before administration, visual acuity of the more severely affected eyes of each patient was counting fingers at 5 feet, 8/200, 20/400, 20/200, and 20/80. Immediately after completion of pulse therapy, visual acuity improved to 20/25 in four patients and 20/30 in one. Remissions were maintained with oral prednisone and external beam irradiation of the orbit. Pulse methylprednisolone therapy appears to be beneficial in the initial management of severe dysthyroid optic neuropathy.

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