Proc Natl Acad Sci U S A. 1978 May;75(5):2453-7.

Model for the incidence of embryonal cancers: application to retinoblastoma.

Abstract

The two-mutation theory of cancer initiation hypothesizes that some cancers originate after two successive mutations, of which the second mutation is always somatic and the first mutation may be germinal (hereditary cases) or somatic (nonhereditary cases). A quantitative model using the Poisson distribution is developed for ages at diagnosis for hereditary and nonhereditary cases. This model relates age-specific incidence data explicitly to the number of divisions of embryonal cells and to rates of somatic mutations per cell division. A good fit is obtained when the model is applied to data on ages at diagnosis for one such embryonal tumor, retinoblastoma.

PMID:: 276883; [PubMed - indexed for MEDLINE]
PMCID:: PMC392572

Free PMC Article

Publication Types, MeSH Terms

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma. [Proc Natl Acad Sci U S A. 1975]
Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma.
Knudson AG Jr, Hethcote HW, Brown BW. Proc Natl Acad Sci U S A. 1975 Dec; 72(12):5116-20.
Mutagenesis and embryonal carcinogenesis. [Natl Cancer Inst Monogr. 1979]
Mutagenesis and embryonal carcinogenesis.
Knudson AG Jr. Natl Cancer Inst Monogr. 1979 May; (51):19-24.
Mutation and cancer: statistical study of retinoblastoma. [Proc Natl Acad Sci U S A. 1971]
Mutation and cancer: statistical study of retinoblastoma.
Knudson AG Jr. Proc Natl Acad Sci U S A. 1971 Apr; 68(4):820-3.
Review Genetic predisposition to cancer. [Cancer Detect Prev. 1984]
Review Genetic predisposition to cancer.
Knudson AG Jr. Cancer Detect Prev. 1984; 7(1):1-8.
Review Genetics and cytogenetics of retinoblastoma. [Cancer Genet Cytogenet. 1992]
Review Genetics and cytogenetics of retinoblastoma.
Horsthemke B. Cancer Genet Cytogenet. 1992 Oct 1; 63(1):1-7.

See reviews... See all...

Cited by 12 PubMed Central articles

Retinoblastoma and the genetic theory of cancer: an old paradigm trying to survive to the evidence. [J Cancer Epidemiol. 2009]
Retinoblastoma and the genetic theory of cancer: an old paradigm trying to survive to the evidence.
Mastrangelo D, Hadjistilianou T, De Francesco S, Loré C. J Cancer Epidemiol. 2009; 2009:301973. Epub 2009 Oct 27.
Rate, molecular spectrum, and consequences of human mutation. [Proc Natl Acad Sci U S A. 2010]
Rate, molecular spectrum, and consequences of human mutation.
Lynch M. Proc Natl Acad Sci U S A. 2010 Jan 19; 107(3):961-8. Epub 2010 Jan 4.
Efficiency of carcinogenesis with and without a mutator mutation. [Proc Natl Acad Sci U S A. 2006]
Efficiency of carcinogenesis with and without a mutator mutation.
Beckman RA, Loeb LA. Proc Natl Acad Sci U S A. 2006 Sep 19; 103(38):14140-5. Epub 2006 Sep 11.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Model for the incidence of embryonal cancers: application to retinoblastoma.
Model for the incidence of embryonal cancers: application to retinoblastoma.
Proc Natl Acad Sci U S A. 1978 May ;75(5):2453-7.

PubMed
Serovars of Vibrio parahaemolyticus.
Serovars of Vibrio parahaemolyticus.
J Hyg Epidemiol Microbiol Immunol. 1989 ;33(2):219-28.

PubMed
Complement C3 convertase: cell surface restriction of beta1H control and generat...
Complement C3 convertase: cell surface restriction of beta1H control and generation of restriction on neuraminidase-treated cells.
Proc Natl Acad Sci U S A. 1978 May ;75(5):2416-20.

PubMed
Fatal infantile muscle phosphorylase deficiency.
Fatal infantile muscle phosphorylase deficiency.
J Child Neurol. 1989 Jul ;4(3):186-8.

PubMed
Anger, hostility, and depression in assaultive vs. suicide-attempting males.
Anger, hostility, and depression in assaultive vs. suicide-attempting males.
J Clin Psychol. 1989 Jul ;45(4):531-41.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: