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Genomics. 1989 Jul;5(1):160-2.

Localization of the gene for uridine monophosphate synthase to human chromosome region 3q13 by in situ hybridization.

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  • 1Department of Biochemical and Clinical Pharmacology, St. Jude Children's Research Hospital, Memphis 38101.

Abstract

The bifunctional enzyme uridine monophosphate (UMP) synthase catalyzes the last two steps in de novo pyrimidine biosynthesis. A genetic deficiency in the activity of this enzyme causes the inherited human disease orotic aciduria. We used a human cDNA probe to localize the gene for UMP synthase to human chromosome region 3q13 by the technique of in situ hybridization.

PMID:
2767686
[PubMed - indexed for MEDLINE]
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