YEATS domain: Linking histone crotonylation to gene regulation

Yuanyuan Li; Dan Zhao; Zhonglei Chen; Haitao Li

doi:10.1080/21541264.2016.1239602

YEATS domain: Linking histone crotonylation to gene regulation

Transcription. 2017 Jan;8(1):9-14. doi: 10.1080/21541264.2016.1239602. Epub 2016 Sep 23.

Authors

Yuanyuan Li¹, Dan Zhao¹, Zhonglei Chen¹, Haitao Li¹

Affiliation

¹ a MOE Key Laboratory of Protein Sciences, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology , Department of Basic Medical Sciences , School of Medicine, Tsinghua University , Beijing , P.R. China.

Abstract

Recent research reveals that the YEATS domains preferentially recognize crotonylated lysines on histones. Here, we discuss the molecular mechanisms that enable this recognition and the biological significances of this interaction. The dynamics of histone crotonylation and its potential roles in the regulation of gene expression will also be discussed.

Keywords: YEATS domain; aromatic-π stacking; histone crotonylation; reader; transcription.

MeSH terms

Gene Expression Regulation, Fungal
Histones / chemistry*
Histones / metabolism*
Models, Molecular
Multigene Family
Protein Processing, Post-Translational
Protein Structure, Tertiary
Saccharomyces cerevisiae / chemistry
Saccharomyces cerevisiae / metabolism*
Saccharomyces cerevisiae Proteins / chemistry*
Saccharomyces cerevisiae Proteins / metabolism*
Transcription, Genetic

Substances

Histones
Saccharomyces cerevisiae Proteins