J Dairy Res. 1989;56(3):363-6.

Opioid antagonist peptides derived from kappa-casein.

Source

Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan.

Abstract

Opioid antagonists were sought in the fragments of kappa-casein which were obtained by chemical synthesis and enzymic digestion. A synthetic bovine kappa-casein peptide (35-41), Tyr-Pro-Ser-Tyr-Gly-Leu-Asn (casoxin A) showed opioid antagonist activity at 200 microM in the guinea pig ileum assay. A synthetic peptide Tyr-Pro-Tyr-Tyr (casoxin B) which is found in bovine and human kappa-casein, also showed opioid antagonist activity at 100 microM. Another opioid antagonist peptide (casoxin C) was isolated from tryptic digests of bovine kappa-casein by reverse-phase HPLC. The structure of the peptide was Tyr-Ile-Pro-Ile-Gln-Tyr-Val-Leu-Ser-Arg, which corresponded to kappa-casein (25-34). Casoxin C was active at 5 microM in the guinea pig ileum assay. Thus, bovine kappa-casein contains three potential opioid antagonist sequences.

PMID:: 2760302; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Medical

Dietary Proteins - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Identification of casoxin C, an ileum-contracting peptide derived from bovine kappa-casein, as an agonist for C3a receptors. [Peptides. 1997]
Identification of casoxin C, an ileum-contracting peptide derived from bovine kappa-casein, as an agonist for C3a receptors.
Takahashi M, Moriguchi S, Suganuma H, Shiota A, Tani F, Usui H, Kurahashi K, Sasaki R, Yoshikawa M. Peptides. 1997; 18(3):329-36.
Isolation and characterization of opioid antagonist peptides derived from human lactoferrin. [Agric Biol Chem. 1990]
Isolation and characterization of opioid antagonist peptides derived from human lactoferrin.
Tani F, Iio K, Chiba H, Yoshikawa M. Agric Biol Chem. 1990 Jul; 54(7):1803-10.
Primary structure of murine major histocompatibility complex alloantigens: amino acid sequence of the amino-terminal one hundred and seventy-three residues of the H-2Kb glycoprotein. [Biochemistry. 1980]
Primary structure of murine major histocompatibility complex alloantigens: amino acid sequence of the amino-terminal one hundred and seventy-three residues of the H-2Kb glycoprotein.
Uehara H, Ewenstein BM, Martinko JM, Nathenson SG, Coligan JE, Kindt TJ. Biochemistry. 1980 Jan 22; 19(2):306-15.
The primary structure of human liver manganese superoxide dismutase. [J Biol Chem. 1984]
The primary structure of human liver manganese superoxide dismutase.
Barra D, Schinina ME, Simmaco M, Bannister JV, Bannister WH, Rotilio G, Bossa F. J Biol Chem. 1984 Oct 25; 259(20):12595-601.
Novel opioid peptides derived from casein (beta-casomorphins). II. Structure of active components from bovine casein peptone. [Hoppe Seylers Z Physiol Chem. ...]
Novel opioid peptides derived from casein (beta-casomorphins). II. Structure of active components from bovine casein peptone.
Henschen A, Lottspeich F, Brantl V, Teschemacher H. Hoppe Seylers Z Physiol Chem. 1979 Sep; 360(9):1217-24.

See reviews... See all...

Cited by 1 PubMed Central article

Shift in the isoelectric-point of milk proteins as a consequence of adaptive divergence between the milks of mammalian species. [Biol Direct. 2011]
Shift in the isoelectric-point of milk proteins as a consequence of adaptive divergence between the milks of mammalian species.
Khaldi N, Shields DC. Biol Direct. 2011 Jul 29; 6:40. Epub 2011 Jul 29.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Opioid antagonist peptides derived from kappa-casein.
Opioid antagonist peptides derived from kappa-casein.
J Dairy Res. 1989 ;56(3):363-6.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: