Angiogenin Defines Heterogeneity at the Core of the Hematopoietic Niche

Cell Stem Cell. 2016 Sep 1;19(3):284-6. doi: 10.1016/j.stem.2016.08.017.

Abstract

Successful hematopoietic regeneration demands preservation of stemness while enabling expansion and differentiation into blood lineages. Now, Silberstein et al. (2016) and Goncalves et al. (2016) identify a ribonuclease secreted by proximal niche cells that simultaneously drives quiescence of HSCs and proliferation of myeloid progenitors and dramatically enhances hematopoietic recovery after HSC transplantation.

Publication types

  • Comment

MeSH terms

  • Cell Differentiation
  • Hematopoietic Stem Cells*
  • Humans
  • Regeneration
  • Stem Cell Niche*