Evidence-based practice (EBP) is essential to high-quality patient care and can contribute to healthcare cost savings, yet nurses and other clinicians at the point of care report barriers to engagement with research and translating it to the clinical setting. Mentorship has been shown to improve nurses' understanding and implementation of EBP. In this article, we describe a mentorship model in a successful program to support point-of-care nurses in conducting small-scale research projects, many of which have led to practice changes and/or cost savings.