Bilateral Atypical Granular Corneal Dystrophy Associated with Unilateral Keratoconus in a Male Child

Kavita Lohiya Dangra; Manoranjan Das; Sundersan Periasamy; N Venkatesh Prajna

doi:10.4103/0974-9233.186151

Bilateral Atypical Granular Corneal Dystrophy Associated with Unilateral Keratoconus in a Male Child

Middle East Afr J Ophthalmol. 2016 Jul-Sep;23(3):262-4. doi: 10.4103/0974-9233.186151.

Authors

Kavita Lohiya Dangra¹, Manoranjan Das¹, Sundersan Periasamy², N Venkatesh Prajna¹

Affiliations

¹ Department of Cornea, Aravind Eye Hospital, Madurai, Tamil Nadu, India.
² Department of Genetics, Aravind Medical Research Foundation, Madurai, Tamil Nadu, India.

Abstract

A 14-year-old male presented with decreased vision. Slit lamp examination indicated multiple anterior corneal stromal opacities with clear intervening spaces accompanied with superficial subepithelial lines arranged in a quasi-whorl-like fashion bilateral with greater prominence in the right eye. Corneal steepening associated with thinning was noted only in the right eye. Genetic analysis confirmed a mutation suggestive of granular corneal dystrophy. Here, we describe a rare case of an atypical granular dystrophy associated with unilateral keratoconus in a male child.

Keywords: Granular Corneal Dystrophy; Keratoconus; Subepithelial Lines.

Publication types

Case Reports

MeSH terms

Adolescent
Corneal Dystrophies, Hereditary / diagnosis
Corneal Dystrophies, Hereditary / etiology*
Corneal Dystrophies, Hereditary / genetics
Corneal Topography
DNA Mutational Analysis
Extracellular Matrix Proteins / genetics
Humans
Keratoconus / complications*
Keratoconus / diagnosis
Keratoconus / genetics
Male
Microscopy, Confocal
Mutation, Missense
Polymorphism, Single Nucleotide
Slit Lamp Microscopy
Tomography, Optical Coherence
Transforming Growth Factor beta / genetics

Substances

Extracellular Matrix Proteins
Transforming Growth Factor beta
betaIG-H3 protein

Supplementary concepts

Groenouw type I corneal dystrophy