The role of FOXP3 in autoimmunity

Curr Opin Immunol. 2016 Dec:43:16-23. doi: 10.1016/j.coi.2016.07.004. Epub 2016 Aug 19.

Abstract

FOXP3 controls the development and function of T regulatory cells (Tregs). Autoimmunity is linked to changes in FOXP3 activity that can occur at multiple levels and lead to Treg dysfunction. For example, changes in IL-2 signaling, FOXP3 transcription and/or post-translational modifications can all contribute to loss of self-tolerance. As additional pathways of FOXP3 regulation are elucidated, new therapeutic approaches to increase Treg activity either by cell therapy or pharmacological intervention are being tested. Early success from pioneering studies of Treg-based therapy in transplantation has promoted the undertaking of similar studies in autoimmunity, with emerging evidence for the effectiveness of these approaches, particularly in the context of type 1 diabetes.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alternative Splicing
  • Animals
  • Autoimmunity
  • Diabetes Mellitus, Type 1 / immunology*
  • Diabetes Mellitus, Type 1 / therapy
  • Forkhead Transcription Factors / genetics
  • Forkhead Transcription Factors / metabolism*
  • Graft Rejection / immunology
  • Graft Rejection / prevention & control*
  • Humans
  • Immunomodulation
  • Immunotherapy / methods*
  • Protein Processing, Post-Translational
  • Protein Transport
  • Self Tolerance
  • Signal Transduction
  • T-Lymphocytes, Regulatory / immunology*
  • T-Lymphocytes, Regulatory / transplantation
  • Transplantation

Substances

  • FOXP3 protein, human
  • Forkhead Transcription Factors