Current and Emerging Therapies of Severe Epileptic Encephalopathies

Abeer J Hani; Mohamad A Mikati

doi:10.1016/j.spen.2016.06.001

Current and Emerging Therapies of Severe Epileptic Encephalopathies

Semin Pediatr Neurol. 2016 May;23(2):180-6. doi: 10.1016/j.spen.2016.06.001. Epub 2016 Jun 3.

Authors

Abeer J Hani¹, Mohamad A Mikati²

Affiliations

¹ Department of Pediatrics and Neurology, Lebanese American University, Byblos, Lebanon.
² Division of Pediatric Neurology, Children's Health Center, Duke University Medical Center, Durham, NC. Electronic address: mohamad.mikati@duke.edu.

PMID: 27544475
DOI: 10.1016/j.spen.2016.06.001

Abstract

In this article, we review the treatment options for the pediatric epileptic encephalopathies and provide an update on the new and emerging therapies targeted at the underlying pathophysiology of many of these syndromes. We illustrate how the identification of the specific genetic and autoimmune causes has made possible the evaluation and development of novel, better targeted therapies, as and at times, avoidance of potentially offending agents.

Publication types

Review

MeSH terms

Anticonvulsants / administration & dosage
Anticonvulsants / pharmacology*
Epilepsies, Myoclonic / drug therapy*
Epilepsies, Myoclonic / genetics
Epilepsies, Myoclonic / immunology
Humans
Infant
Landau-Kleffner Syndrome / drug therapy*
Landau-Kleffner Syndrome / genetics
Landau-Kleffner Syndrome / immunology
Lennox Gastaut Syndrome / drug therapy*
Lennox Gastaut Syndrome / genetics
Lennox Gastaut Syndrome / immunology
Spasms, Infantile / drug therapy*
Spasms, Infantile / genetics
Spasms, Infantile / immunology

Substances

Anticonvulsants

Supplementary concepts

Infantile Epileptic-Dyskinetic Encephalopathy