Science. 1989 Jul 14;245(4914):188-90.

The periaqueductal gray matter mediates opiate-induced immunosuppression.

Source

Laboratory of Medicinal Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD 20892.

Abstract

The periaqueductal gray matter of the mesencephalon (PAG) subserves a variety of diverse autonomic functions and also appears to be a site for opiate action in the induction of immunosuppression. Microinjections of morphine into the PAG, but not into other opiate receptor-containing neuroanatomical sites, result in a rapid suppression of natural killer (NK) cell activity. The NK cell suppression can be blocked by prior peripheral administration of the opiate antagonist naltrexone. These findings demonstrate that certain central actions of opiates that produce changes in NK cell function are mediated through opiate receptors in the PAG and identify a brain region involved in opiate regulation of immune function.

PMID:: 2749256; [PubMed - indexed for MEDLINE]

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Chemical compound information

Morphine

MW: 285.33 g/mol

MF: C₁₇H₁₉NO₃

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