Abstract
The article presents data on levels of osteocalcin and pyridinoline in patients with systemic lupus erythematosus (SLE), their comparison with structural and functional state of bone tissue and course of the disease. Bone metabolism derangements were found in 65.8% of women with SLE. Herewith, the increase of pyridinoline content was observed in 43.9% of patients, the reduction of osteocalcinin 39% of individuals. The deterioration of bone metabolism was associated with the severity of the disease, especially high levels of C-reactive protein (CRP) and interleukin-6 (IL-6) (r = 0.3-0.32), cumulative dose of glucocorticoids (GC) and low body mass index (BMI). Among patients with signs of biosynthetic inhibition and increasing of destructive processes in bone tissue were more often met people with osteopenia and osteoporosis. osteoporosis.
MeSH terms
-
Absorptiometry, Photon
-
Adult
-
Amino Acids / blood*
-
Biomarkers / blood
-
Body Mass Index
-
Bone Density / drug effects
-
Bone Resorption / blood*
-
Bone Resorption / complications
-
Bone Resorption / diagnostic imaging
-
Bone Resorption / pathology
-
C-Reactive Protein / metabolism
-
Case-Control Studies
-
Disease Progression
-
Female
-
Glucocorticoids / adverse effects
-
Humans
-
Interleukin-6 / blood
-
Lumbar Vertebrae / diagnostic imaging
-
Lumbar Vertebrae / drug effects
-
Lumbar Vertebrae / metabolism
-
Lumbar Vertebrae / pathology
-
Lupus Erythematosus, Systemic / blood*
-
Lupus Erythematosus, Systemic / complications
-
Lupus Erythematosus, Systemic / diagnostic imaging
-
Lupus Erythematosus, Systemic / pathology
-
Middle Aged
-
Osteocalcin / blood*
-
Osteoporosis / blood*
-
Osteoporosis / complications
-
Osteoporosis / diagnostic imaging
-
Osteoporosis / pathology
-
Severity of Illness Index
Substances
-
Amino Acids
-
Biomarkers
-
Glucocorticoids
-
IL6 protein, human
-
Interleukin-6
-
Osteocalcin
-
pyridinoline
-
C-Reactive Protein