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A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies.
Dis Model Mech. 2016 Sep 1;9(9):975-84. doi: 10.1242/dmm.025890. Epub 2016 Aug 4.
Dis Model Mech. 2016.
PMID: 27491072
Free PMC article.
Stomachs of mice lacking the gastric H,K-ATPase alpha -subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia.
Spicer Z, Miller ML, Andringa A, Riddle TM, Duffy JJ, Doetschman T, Shull GE.
Spicer Z, et al.
J Biol Chem. 2000 Jul 14;275(28):21555-65. doi: 10.1074/jbc.M001558200.
J Biol Chem. 2000.
PMID: 10764766
Free article.
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