Coming or going? Un-BLOC-ing delivery and recycling pathways during melanosome maturation

Clare E Futter; Daniel F Cutler

doi:10.1083/jcb.201607023

Coming or going? Un-BLOC-ing delivery and recycling pathways during melanosome maturation

J Cell Biol. 2016 Aug 1;214(3):245-7. doi: 10.1083/jcb.201607023.

Authors

Clare E Futter¹, Daniel F Cutler²

Affiliations

¹ Univeristy College London Institute of Ophthalmology, London EC1V 9EL, England, UK c.futter@ucl.ac.uk.
² Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, England, UK.

Abstract

Melanosome biogenesis requires successive waves of cargo delivery from endosomes to immature melanosomes, coupled with recycling of the trafficking machinery. Dennis et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201605090) report differential roles for BLOC-1 and BLOC-3 complexes in delivery and recycling of melanosomal biogenetic components, supplying directionality to melanosome maturation.

MeSH terms

Animals
Carrier Proteins / metabolism*
Cell Differentiation*
Endocytosis*
Endosomes / metabolism
Humans
Melanosomes / metabolism*
Models, Biological

Substances

Carrier Proteins

Abstract

MeSH terms

Substances

Grants and funding