Monocyte Chemoattractant Protein-1 and Large Artery Structure and Function in Young Individuals: The African-PREDICT Study

J Clin Hypertens (Greenwich). 2017 Jan;19(1):67-74. doi: 10.1111/jch.12868. Epub 2016 Jul 25.

Abstract

To better understand hypertension development, the authors determined whether monocyte chemoattractant protein-1 (MCP-1) is associated with arterial stiffness (pulse wave velocity [PWV]) and carotid intima-media wall thickness (cIMT) in a young apparently healthy black and white population (N=403, aged 20-30 years). Carotid-femoral PWV, central systolic blood pressure, and cIMT were measured, and MCP-1, reactive oxygen species, inflammatory markers (interleukin 6, tumor necrosis factor α), and endothelial activation (intercellular adhesion molecule, vascular cell adhesion molecule) were determined from blood samples. Although carotid-femoral PWV and cIMT were similar between blacks and whites, black men and women showed higher central systolic blood pressure, MCP-1, and reactive oxygen species than whites (all P<.05). In addition, black women had higher brachial blood pressure and interleukin 6 (all P<.001). A consistent positive association only in black women between cIMT and MCP-1 in multiple regression analyses was found (R²=0.151, β=0.248; P=.021). In this model, cIMT was also independently associated with vascular cell adhesion molecule (β=0.251; P=.022). The authors found elevated central systolic blood pressure and MCP-1 in young blacks, where cIMT was independently associated with MCP-1 in black women.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Pressure
  • Carotid Arteries / metabolism
  • Carotid Arteries / physiopathology*
  • Carotid Intima-Media Thickness
  • Chemokine CCL2 / blood*
  • Female
  • Humans
  • Hypertension / ethnology
  • Hypertension / metabolism*
  • Hypertension / physiopathology
  • Male
  • Pulse Wave Analysis
  • South Africa / ethnology
  • Vascular Stiffness
  • Young Adult

Substances

  • CCL2 protein, human
  • Chemokine CCL2