Depth-resolved measurements with elliptically polarized reflectance spectroscopy

Maria J Bailey; Konstantin Sokolov

doi:10.1364/BOE.7.002861

Depth-resolved measurements with elliptically polarized reflectance spectroscopy

Biomed Opt Express. 2016 Jun 28;7(7):2861-76. doi: 10.1364/BOE.7.002861. eCollection 2016 Jul 1.

Authors

Maria J Bailey¹, Konstantin Sokolov²

Affiliations

¹ Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA.
² Department of Imaging Physics, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA; Department of Bioengineering, Rice University, Houston, TX 77005, USA.

Abstract

The ability of elliptical polarized reflectance spectroscopy (EPRS) to detect spectroscopic alterations in tissue mimicking phantoms and in biological tissue in situ is demonstrated. It is shown that there is a linear relationship between light penetration depth and ellipticity. This dependence is used to demonstrate the feasibility of a depth-resolved spectroscopic imaging using EPRS. The advantages and drawbacks of EPRS in evaluation of biological tissue are analyzed and discussed.

Keywords: (170.6510) Spectroscopy, tissue diagnostics; (290.0290) Scattering; (290.5855) Scattering, polarization; (300.0300) Spectroscopy.

Abstract

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