Early Bronchus-Associated Lymphoid Tissue Lymphoma Diagnosed with Immunoglobulin Heavy Chain Molecular Testing

Can Respir J. 2016:2016:7056035. doi: 10.1155/2016/7056035. Epub 2016 Mar 31.

Abstract

When extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT), a low grade B-cell lymphoma, arises in the lung it is referred to as bronchus-associated lymphoid tissue (BALT) lymphoma. We describe a patient with a history of Sjögren's syndrome and rheumatoid arthritis with dyspnea and imaging consistent with lymphoid interstitial pneumonia (LIP). However, while histology and immunohistochemistry lacked definitive features of a lymphoma, immunoglobulin heavy chain (IgH) polymerase chain reaction testing demonstrated B-cell monoclonality, consistent with an early BALT lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / drug therapy
  • Bronchial Neoplasms / complications
  • Bronchial Neoplasms / diagnostic imaging*
  • Bronchial Neoplasms / genetics
  • Bronchial Neoplasms / pathology
  • Cough / etiology
  • Dyspnea / etiology
  • Female
  • Gene Rearrangement, B-Lymphocyte, Heavy Chain / genetics
  • Humans
  • Immunoglobulin Heavy Chains / genetics
  • Infliximab / therapeutic use
  • Lymphoma, B-Cell, Marginal Zone / complications
  • Lymphoma, B-Cell, Marginal Zone / diagnostic imaging*
  • Lymphoma, B-Cell, Marginal Zone / genetics
  • Lymphoma, B-Cell, Marginal Zone / pathology
  • Polymerase Chain Reaction
  • Sjogren's Syndrome / complications
  • Sjogren's Syndrome / drug therapy
  • Tomography, X-Ray Computed

Substances

  • Immunoglobulin Heavy Chains
  • Infliximab