Abstract
When extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue (MALT), a low grade B-cell lymphoma, arises in the lung it is referred to as bronchus-associated lymphoid tissue (BALT) lymphoma. We describe a patient with a history of Sjögren's syndrome and rheumatoid arthritis with dyspnea and imaging consistent with lymphoid interstitial pneumonia (LIP). However, while histology and immunohistochemistry lacked definitive features of a lymphoma, immunoglobulin heavy chain (IgH) polymerase chain reaction testing demonstrated B-cell monoclonality, consistent with an early BALT lymphoma.
MeSH terms
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Aged
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Arthritis, Rheumatoid / complications
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Arthritis, Rheumatoid / drug therapy
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Bronchial Neoplasms / complications
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Bronchial Neoplasms / diagnostic imaging*
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Bronchial Neoplasms / genetics
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Bronchial Neoplasms / pathology
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Cough / etiology
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Dyspnea / etiology
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Female
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Gene Rearrangement, B-Lymphocyte, Heavy Chain / genetics
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Humans
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Immunoglobulin Heavy Chains / genetics
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Infliximab / therapeutic use
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Lymphoma, B-Cell, Marginal Zone / complications
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Lymphoma, B-Cell, Marginal Zone / diagnostic imaging*
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Lymphoma, B-Cell, Marginal Zone / genetics
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Lymphoma, B-Cell, Marginal Zone / pathology
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Polymerase Chain Reaction
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Sjogren's Syndrome / complications
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Sjogren's Syndrome / drug therapy
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Tomography, X-Ray Computed
Substances
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Immunoglobulin Heavy Chains
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Infliximab