Non-invasive tumescent cryolipolysis using a new 4D handpiece: a comparative study with a porcine model

Skin Res Technol. 2017 Feb;23(1):79-87. doi: 10.1111/srt.12305. Epub 2016 Jul 20.

Abstract

Background/purpose: The growing demand for a youthful appearance, including a favorable body shape, has motivated recent developments in noninvasive body contouring techniques. Our aim was to investigate the efficacy and safety of a new version of a 4D handpiece-mounted cooling device for cryolipolysis with or without tumescent injections.

Methods: We conducted a side-by-side comparative study using two female porcine models. Two areas of each pig's left abdomen were treated using a conventional device and the new cooling device, and two areas of the right abdomen were also treated using the conventional and new cooling device, but both were combined with tumescent-solution injections.

Results: The conventional method alone yielded a 75.25% reduction in skin thickness, while the new cooling device alone yielded a 81.63% reduction. When paired with tumescent injections, the conventional device yielded a 86.3% reduction in skin thickness and the cooling device yielded a 85.9% reduction. Using histological analysis with H&E, oil red O, and toluidine blue stain, we confirmed that selective cryolipolysis was able to induce selective apoptosis of fat cells.

Conclusion: This in vivo study presents a new 4D handpiece-assisted cooling device with tumescent anesthesia that is safe and effective for fat reduction.

Keywords: 4D handpiece; cryolipolysis; fat; tumescent.

Publication types

  • Comparative Study
  • Evaluation Study
  • Validation Study

MeSH terms

  • Adipose Tissue / pathology*
  • Adipose Tissue / surgery*
  • Animals
  • Cosmetic Techniques / instrumentation*
  • Cryosurgery / instrumentation*
  • Cryosurgery / methods
  • Dermatologic Surgical Procedures / instrumentation*
  • Equipment Design
  • Equipment Failure Analysis
  • Female
  • Lipectomy / instrumentation*
  • Lipectomy / methods
  • Miniaturization
  • Swine