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Acta Anat (Basel). 1989;134(4):276-82.

Ultrastructural features of skeletal muscle in mice after physical exercise: its relation to the pathogenesis of leucocyte invasion.

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  • 1Institut für Anatomie der Medizinischen Universität zu Lübeck, BRD.


This study was designed to elucidate which factor(s) trigger off the enhanced macrophage activity after strenuous physical exercise. For an understanding of the cause of this phenomenon we extended the study of the ultrastructural features of skeletal muscle after physical exercise to its possible relation to the pathogenesis of leucocyte invasion. Ultrastructural investigations revealed muscle damage after a strenuous physical exercise. The pathogenesis of the detected autolytic alterations could be related to a local accumulation of lactate, to the ischemic compression syndrome, to an insufficient oxygen supply or to anatomical peculiarities. The greatest functional claim was that fibrillolytic degeneration was capable of being triggered off in the skeletal muscular structure, thereby initiating the release of filament fragments, whose peptides were capable of being depicted as chemotactic signals for leucocytes. The appearance of leucocytes in the muscular tissue suggests that the basic humoral immunity reactions control the cellular cooperation in the muscular tissue.

[PubMed - indexed for MEDLINE]
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