Tris-ureas as transmembrane anion transporters

Dalton Trans. 2016 Aug 7;45(29):11892-7. doi: 10.1039/c6dt02046a. Epub 2016 Jul 6.

Abstract

Nine tris-urea receptors (L(1)-L(9)) have been synthesised and shown to coordinate to a range of anionic guests both by (1)H NMR titration techniques and single crystal X-ray structural analysis. The compounds have been shown to be capable of mediating the exchange of chloride and nitrate and also chloride and bicarbonate across POPC or POPC : cholesterol 7 : 3 vesicle bilayer membranes at low transporter loadings. An interesting dependency of anion transport on the nature of the cation is evidence to suggest that a M(+)/Cl(-) cotransport process may also contribute to the release of chloride from the vesicles.

MeSH terms

  • Bicarbonates / chemistry
  • Chlorides / chemistry
  • Cholesterol / chemistry
  • Lipid Bilayers / chemistry
  • Membrane Transport Proteins / chemistry*
  • Nitrates / chemistry
  • Phosphatidylcholines / chemistry
  • Urea / analogs & derivatives*
  • Urea / chemistry*

Substances

  • Bicarbonates
  • Chlorides
  • Lipid Bilayers
  • Membrane Transport Proteins
  • Nitrates
  • Phosphatidylcholines
  • Urea
  • Cholesterol
  • 1-palmitoyl-2-oleoylphosphatidylcholine