Tunable Lipidoid-Telodendrimer Hybrid Nanoparticles for Intracellular Protein Delivery in Brain Tumor Treatment

Xu Wang; Alexa Bodman; Changying Shi; Dandan Guo; Lili Wang; Juntao Luo; Walter A Hall

doi:10.1002/smll.201601234

Tunable Lipidoid-Telodendrimer Hybrid Nanoparticles for Intracellular Protein Delivery in Brain Tumor Treatment

Small. 2016 Aug;12(31):4185-92. doi: 10.1002/smll.201601234. Epub 2016 Jul 4.

Authors

Xu Wang¹, Alexa Bodman², Changying Shi¹, Dandan Guo¹, Lili Wang¹, Juntao Luo¹, Walter A Hall²

Affiliations

¹ Department of Pharmacology, Upstate Cancer Center, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.
² Department of Neurosurgery, State University of New York Upstate Medical University, Syracuse, NY, 13210, USA.

Abstract

A strategy to precisely engineer lipidoid-telodendrimer binary hybrid nanoparticles that offer enhanced cell membrane permeability for therapeutic proteins to reach the intracellular targets is established. The highly controllable biochemical and physical properties of the nanoparticles make them promising for protein-based brain cancer treatment with the assistance of convection-enhanced delivery.

Keywords: glioblastoma; lipidoids; nanoparticles; protein delivery; telodendrimers.

MeSH terms

Animals
Brain Neoplasms / drug therapy*
Brain Neoplasms / metabolism
Cell Line, Tumor
Humans
Lipids / chemistry*
Models, Theoretical
Nanoparticles / chemistry*
Proteins / administration & dosage*
Proteins / chemistry*
Proteins / therapeutic use

Substances

Lipids
Proteins

Abstract

MeSH terms

Substances

Grants and funding