Fat, Stem Cells, and Platelet-Rich Plasma

Isaac B James; Sydney R Coleman; J Peter Rubin

doi:10.1016/j.cps.2016.03.017

Fat, Stem Cells, and Platelet-Rich Plasma

Clin Plast Surg. 2016 Jul;43(3):473-88. doi: 10.1016/j.cps.2016.03.017.

Authors

Isaac B James¹, Sydney R Coleman², J Peter Rubin³

Affiliations

¹ Department of Plastic Surgery, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA.
² Department of Plastic Surgery, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA; Department of Plastic Surgery, New York University Langone Medical Center, 44 Hudson Street, New York, NY 10013, USA; Private Practice, Tribeca Plastic Surgery, New York, NY.
³ Department of Plastic Surgery, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA; Department of Bioengineering, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15261, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, PA 15261, USA. Electronic address: rubipj@UPMC.EDU.

PMID: 27363761
DOI: 10.1016/j.cps.2016.03.017

Abstract

The ideal filler for aesthetic surgery is inexpensive and easy to obtain, natural in appearance and texture, immunologically compatible, and long lasting without risk of infection. By most metrics, autologous fat grafts meet these criteria perfectly. Although facial fat grafting is now a commonly accepted surgical procedure, there has been a wave of activity applying stem cells and platelet-rich plasma (PRP) therapies to aesthetic practice. This article addresses technical considerations in the use of autologous fat transfer for facial rejuvenation, and also explores the current evidence for these stem cell and PRP therapies in aesthetic practice.

Keywords: Adipose-derived stem cells; Autologous fat; Coleman technique; Facial augmentation; Facial rejuvenation; Fat; Fat grafting; Lipoaspirate; PRP; Platelet-rich plasma; Regenerative medicine; Stem cells; Stromal vascular fraction; Structural fat grafting.

Publication types

Review

MeSH terms

Adipose Tissue / transplantation*
Cosmetic Techniques
Dermal Fillers*
Face / surgery*
Humans
Platelet-Rich Plasma*
Regenerative Medicine
Rejuvenation*
Skin Aging
Stem Cell Transplantation*

Substances

Dermal Fillers