Ruthenium-Catalyzed C-H Alkynylation of Aromatic Amides with Hypervalent Iodine-Alkyne Reagents

Org Lett. 2016 Jul 15;18(14):3314-7. doi: 10.1021/acs.orglett.6b01281. Epub 2016 Jun 30.

Abstract

An efficient C-H activation method for the ortho alkynylation of aromatic N-methoxyamides with hypervalent iodine-alkyne reagent using a ruthenium catalyst is described. The reaction proceeds under mild reaction conditions with broad substrate scope. A possible catalytic cycle involving a ruthenium carboxylate assisted C-H bond cleavage is proposed from the preliminary mechanistic evidence.

Publication types

  • Research Support, Non-U.S. Gov't