Feverish Quest for Ebola Immunotherapy: Straight or Cocktail?

Trends Microbiol. 2016 Sep;24(9):684-686. doi: 10.1016/j.tim.2016.05.008. Epub 2016 Jun 20.

Abstract

The ebolavirus immunotherapeutics field has replaced previous perceptions of antibody inadequacy with a new abundance of monoclonals exhibiting post exposure efficacy. Now the questions are: what epitopes to target, what immunological mechanisms to seek, whether species-specific or broadly reactive antibodies are best, and whether a cocktail or monotherapy should be used.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology
  • Antibodies, Monoclonal / therapeutic use*
  • Antibodies, Neutralizing / immunology
  • Antibodies, Neutralizing / therapeutic use*
  • Antibodies, Viral / immunology
  • Antibodies, Viral / therapeutic use*
  • Ebolavirus / immunology*
  • Epitopes / immunology
  • Hemorrhagic Fever, Ebola / therapy*
  • Hemorrhagic Fever, Ebola / virology
  • Humans
  • Immunotherapy / methods*
  • Mice
  • Viral Envelope Proteins / immunology*

Substances

  • Antibodies, Monoclonal
  • Antibodies, Neutralizing
  • Antibodies, Viral
  • Epitopes
  • Viral Envelope Proteins
  • envelope glycoprotein, Ebola virus