Clinical feasibility of Gd-EOB-DTPA-enhanced MR imaging for assessing liver function: validation with ICG tests and parenchymal cell volume

Chin-Chen Chang; Hsu-Cheng Huang; Kao-Lang Liu; Yao-Ming Wu; Jason J S Lee; Shu-Fen Jiang; Mao-Yuan M Su

doi:10.1016/j.clinimag.2016.03.003

Clinical feasibility of Gd-EOB-DTPA-enhanced MR imaging for assessing liver function: validation with ICG tests and parenchymal cell volume

Clin Imaging. 2016 Jul-Aug;40(4):797-800. doi: 10.1016/j.clinimag.2016.03.003. Epub 2016 Mar 9.

Authors

Chin-Chen Chang¹, Hsu-Cheng Huang², Kao-Lang Liu³, Yao-Ming Wu⁴, Jason J S Lee⁵, Shu-Fen Jiang⁶, Mao-Yuan M Su⁷

Affiliations

¹ Departments of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung-Shan South Road, Taipei 100, Taiwan; Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, No.155, Sec. 2, Li-Nong St., Taipei 112, Taiwan. Electronic address: macotocc@gmail.com.
² Departments of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung-Shan South Road, Taipei 100, Taiwan. Electronic address: hjround@gmail.com.
³ Departments of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung-Shan South Road, Taipei 100, Taiwan. Electronic address: lkl@ntu.edu.tw.
⁴ Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung-Shan South Road, Taipei 100, Taiwan. Electronic address: wyaoming@gmail.com.
⁵ Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, No.155, Sec. 2, Li-Nong St., Taipei 112, Taiwan. Electronic address: jslee@ym.edu.tw.
⁶ Departments of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung-Shan South Road, Taipei 100, Taiwan. Electronic address: jiangfen1215@hotmail.com.
⁷ Departments of Medical Imaging, National Taiwan University Hospital and National Taiwan University College of Medicine, No.7, Chung-Shan South Road, Taipei 100, Taiwan. Electronic address: maoyuansu@gmail.com.

PMID: 27317227
DOI: 10.1016/j.clinimag.2016.03.003

Abstract

Objective: Using Gd-EOB-DTPA-enhanced MRI to assess liver function and validate with indocyanine green (ICG) tests and parenchymal cell volume (PCV).

Methods: Nineteen patients scheduled for operation were enrolled. Functional liver volume (FLV) was computed from 20min post-contrast images. ICG retention was measured in serum 15min after injection. The histological PCV was determined from resected liver specimen.

Results: FLV showed significantly correlated with ICG retention (ICG-R15: r=-0.47, P=.042) and PCV (r=0.814, P<.001).

Conclusions: Gd-EOB-DTPA-enhanced MRI is clinically feasible for quantifying liver function.

Keywords: Gd-EOB-DTPA; chronic liver disease; indocyanine green; liver fibrosis; magnetic resonance imaging.

Publication types

Validation Study

MeSH terms

Adult
Aged
Cell Size
Contrast Media*
Feasibility Studies
Female
Gadolinium DTPA*
Humans
Image Enhancement / methods*
Indocyanine Green*
Liver / diagnostic imaging
Liver / pathology*
Liver / physiopathology
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Reproducibility of Results

Substances

Contrast Media
gadolinium ethoxybenzyl DTPA
Indocyanine Green
Gadolinium DTPA